Proteins & Antibodies

Human FcRn

Catalog # Size Price Quantity
E1032 100 µg $550.00

This recombinant Human FcRn protein (the neonatal Fc receptor) is made from HEK-293 cells and fused with a polyhistidine tag at the C-terminus.

Binds to human IgG in a pH-dependent manner.

The neonatal Fc receptor (FcRn) is responsible for transporting maternal IgGs to fetus/newborns and maintaining the homeostasis of IgGs in adults. FcRn resembles class I major histocompatibility complex in structure, and is composed of a transmembrane heavy chain and an invariant β2 microglobulin. Changes in the affinity of IgGs to to FcRn lead to changes in the half-life of engineered IgGs and Fc fusion proteins. Longer half-life of therapeutic antibodies means lower dose and longer interval between administering. For some diagnostic agents, including imaging or radio-labeled agents, a shorter half-life in circulation results in lower non-specific binding and decreased side effects. Therefore, studying the interaction of FcRn and therapeutic antibodies has direct clinical implications. 


0.2 μM filtered solution of 20 mM HEPES, 150 mM NaCl, pH 7.5


This protein should be stored at -80°C.
Stable at < -20°C for 3 months or at 4°- 7°C for 3 weeks.
Minimize repeated freeze-thaw cycles.


Purity is greater than 95%.