DESCRIPTION:
This recombinant human GLP1R protein
is made from HEK-293 cells. The polypeptide sequence is the sequence of human
GLP1R extracellular domain (corresponding to amino acids 24-145) fused to a
polyhistidine tag at the N-terminus. This GLP1R ECD protein is useful for any in
vitro study with relevance to weight control, diabetes, and GLP1 pathway.
Also known as: GLP-1 receptor,
GLP-1-R,GLP-1R.
BACKGROUND:
Human GLP1R (Glucagon-like Peptide 1
Receptor) is a receptor for Glucagon-like Peptide (GLP-1), a regulator of
insulin secretion by pancreatic beta cells. It is a class B, G protein-linked protein
with 7 transmembrane domains that is expressed in the pancreas, lungs, heart,
kidneys, hypothalamus, and stomach. GLP-1 has health relevance as it has been
shown to reduce body weight, which is a favorable
condition for many people with type 2 diabetes. Known agonists for GLP1R
include GLP-1, Boc5, and Cpd1.
FORMULATION:
0.2 µM filtered solution of 30 mM
HEPES, 150 mM NaCl, pH 7.0.
STORAGE:
This protein should be stored
at -80°C.
Stable at < -20°C for 3 months or
at 4° - 7°C for 3 weeks.
Minimize repeated freeze-thaw
cycles.
QUALITY CONTROL: >95% pure
