DESCRIPTION:
This recombinant Human PDL1 protein is made from HEK293 cells. It is secreted with the sequence of Human PDL1 (amino acids 19-239) fused with a FLAG tag at the C-terminus. Also known as: PD-L1, PDCD1 ligand 1, programmed death ligand 1, cluster of differentiation 274 (CD274), B7 homolog 1 (B7-H1).
BACKGROUND:
Programmed Death Ligand 1 (PDL1) is a member of the growing B7 family of immune proteins that provide signals for both stimulating and inhibiting T cell activation. It is a 40kDa type 1 transmembrane protein that has been speculated to play a major role in suppressing the immune system during particular events such as pregnancy, tissue allografts, autoimmune disease and other disease states such as hepatitis. PD-L1 binds to its receptor, PD-1, found on activated T cells, B cells, and myeloid cells, to modulate activation or inhibition.
FORMULATION:
0.2 µM filtered solution of 100 mM HEPES, 0.2% sodium acetate, pH 6
STORAGE:
This Protein should be stored at -80ºC.
Stable at < -20ºC for 3 months or at 4° - 7°C for 3 weeks.
Minimize repeated freeze-thaw cycles.
QUALITY CONTROL:
Purity is greater than 95%.
