DESCRIPTION
This recombinant Human Activin Receptor protein is made from 293 cells. It is secreted with the sequence
of Human Activin Receptor type IIB (amino acids 20-136) fused with a human IgG1 Fc tag at the C-terminus.
Also known as: Activin receptor type IIB, ACTR-IIB, ACVR2B.
BACKGROUND
Members of the transforming growth factor b superfamily bind to a pair of transmembrane proteins, known
as receptor types I and II, which contain serine/threonine kinases and associate to form a signaling
complex. Either a type I or type II receptor may initially bind a ligand, followed by recruitment of its alternate-type
receptor counterpart to generate a heteromeric signaling complex. Type I receptors are referred to as
the Activin Receptor-like Kinases (ALKs), while the type II receptors are named for the ligands they bind.
Activin has been shown to bind a heteromeric noncovalent complex, which consists of a type I receptor,
ACTR-IA or ACTR-IB, and a type II receptor, ACTR-IIA or ACTR-IIB (also designated ACVR2B). The
activin receptor family members are thought to mediate distinct effects on gene expression, cell
differentiation, and morphogenesis in a dose dependent fashion.
FORMULATION
0.2 μM filtered solution of 50 mM Tris, 150 mM NaCl, pH 7.5
STORAGE
This Protein should be stored at -80°C.
Stable at < -20°C for 3 months or at 4° - 7°C for 3 weeks.
Minimize repeated freeze-thaw cycles.
QUALITY CONTROL
Purity is greater than 95%.
